Amacrine cells

Amacrine cells

Amacrine cells interact with bipolar cells and/or ganglion cells. They are a type of interneuron that monitor and augment the stream of data through bipolar cells and also control and refine the response of ganglion cells and their subtypes.

Amacrine cells are in a central but inaccessible region of the retinal circuitry. Most are without tale-like axons. Whilst they clearly have multiple connections to other neurons around them, their precise inputs and outputs are difficult to trace. They are driven by and send feedback to the bipolar cells but also synapse on ganglion cells, and with each other.

Amacrine cells are known to serve narrowly task-specific visual functions including:

  • Efficient transmission of high-fidelity visual information with a good signal-to-noise ratio.
  • Maintaining the circadian rhythm, so keeping our lives tuned to the cycles of day and night and helping to govern our lives throughout the year.
  • Measuring the difference between the response of specific photoreceptors compared with surrounding cells (centre-surround antagonism) which enables edge detection and contrast enhancement.
  • Object motion detection which provides an ability to distinguish between the true motion of an object across the field of view and the motion of our eyes.

Centre-surround antagonism refers to the way retinal neurons organize their receptive fields. The centre component is primed to measure the sum-total of signals received from a small number of cones directly connected to a bipolar cell. The surround component is primed to measure the sum of signals received from a much larger number of cones around the centre point. The two signals are then compared to find the degree to which they agree or disagree.